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Inhibition of recombinant human PTPbeta using DiFMUP as substrate at 10 uM preincubated for 10 mins followed by substrate addition and measured after 2 hrs relative to control
Assay data:4 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant human PTPbeta using DiFMUP as substrate preincubated for 10 mins followed by substrate addition and measured after 2 hrs
Assay data:21 Active, 2 Activity ≤ 1 µM, 25 Tested
Inhibitory Activity to HPTP-β from US Patent US11666558: "Methods of treating intraocular pressure with activators of Tie-2"
Assay data:97 Active, 32 Activity ≤ 1 nM, 95 Activity ≤ 1 µM, 97 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of PTPbeta (unknown origin)
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US11413242: "Formulations of Tie-2 activators and methods of use thereof"
Assay data:97 Active, 32 Activity ≤ 1 nM, 84 Activity ≤ 1 µM, 97 Tested
Inhibitory Activity Assay from US Patent US10952992: "Methods of treating intraocular pressure with activators of Tie-2"
Enzyme Kinetic Assay from US Patent US9340574: "Inhibitors of protein tyrosine phosphatases"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
HPTP Assay from US Patent US10220048: "Compositions and methods for treating ocular diseases"
Inhibition of His-tagged PTPbeta (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis
Assay data:9 Tested
Inhibition of PTPB (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric method
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human RTP Type B (Receptor tyrosine phosphatase (RTP) family)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant HPTPbeta (unknown origin) preincubated for 10 mins followed by substrate addition measured after 15 mins by DiFMUP probe-based fluorescence assay
Assay data:98 Active, 45 Activity ≤ 1 nM, 98 Activity ≤ 1 µM, 98 Tested
Inhibition of PTPbeta (unknown origin) using pNPP as substrate at 200 uM after 5 mins by spectrophotometry
Assay data:1 Tested
Inhibition of phosphatase activity of human PTPbeta using pNPP as a substrate after 10 mins by spectrophotometer analysis
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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