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Agonist activity at human RARgamma (177 to 462 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Transactivation assays from US Patent US10752616: "Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists"
Assay data:46 Active, 2 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Competitive Assay from Article 10.1016/S1074-5521(99)80084-2: "Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists."
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Retinoid Competition Binding Assay from Article 10.1006/jmbi.2000.4032: "Structural basis for isotype selectivity of the human retinoic acid nuclear receptor."
Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Retinoid Nuclear Receptor Activity from US Patent US10188615: "Alkoxy compounds for disease treatment"
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity RARgamma (unknown origin) assessed as induction of receptor transactivation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at RAR (unknown origin) by Alpha Screen assay
Agonist activity at RAR (unknown origin) by Alpha Screen assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Agonist activity at RAR (unknown origin) at 10 uM
Agonist activity at human Gal4-DBD fused RARgamma LBD expressed in HEK293T cells at 30 uM after 12 to 14 hrs by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at Gal4-LBD fused RARgamma (unknown origin) expressed in HEK293T cells after at 10 uM 14 to 16 hrs by dual-Glo luciferase assay
Assay data:2 Active, 2 Tested
Agonist activity at Gal4-LBD fused RARgamma (unknown origin) expressed in HEK293T cells after at 20 uM 14 to 16 hrs by dual-Glo luciferase assay
Agonist activity at RAR gamma (unknown origin)
Assay data:2 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at GAL4-tagged human RARgamma isoform 1 ligand binding domain (179 to 454 residues) expressed in HEK293T cells at 1 uM after 12 to 14 hrs by dual-glo luciferase reporter gene assay
Transactivation of GAL4-tagged human RARgamma isoform 1 ligand binding domain (179 to 454 residues) expressed in HEK293T cells at 1 uM after 12 to 14 hrs by dual-glo luciferase reporter gene assay
Agonist activity at RARgamma (unknown origin)
Assay data:3 Tested
Transactivation of human GAL4-fused RARgamma ligand binding domain expressed in HEL293T cells at 10 uM after 12 to 14 hrs by dual-glo luciferase reporter gene assay
Agonist activity at RARgamma (unknown origin) expressed in human MCF-7 cells assessed as increase in AHPN induced receptor transactivation at 10 uM after 24 hrs by luciferase reporter gene assay
Assay data:4 Tested
Antagonist activity at RARgamma (unknown origin) expressed in human MCF-7 cells assessed as inhibition of AHPN induced receptor transactivation at 10 uM after 24 hrs by luciferase reporter gene assay
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