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RET Enzyme Assay from US Patent US11851434: "Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors"
Assay data:114 Active, 113 Activity ≤ 1 µM, 114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of RET Family Kinases Activity from US Patent US20230322769: "HETEROAROMATIC RING COMPOUND AS RET KINASE INHIBITOR, AND PREPARATION AND USE THEREOF"
Assay data:32 Active, 3 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Inhibitory Activity Evaluation of Human Wild-type and V804M Mutant RET Kinase from US Patent US20230312504: "QUINOLINE COMPOUNDS"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
RET and KDR Enzyme Assay from US Patent US11680068: "Compounds useful as RET inhibitors"
Assay data:52 Active, 1 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 55 Tested
RET and KDR Enzyme Assay from US Patent US11661423: "Heterocyclic compounds as RET kinase inhibitors"
Assay data:84 Active, 3 Activity ≤ 1 nM, 80 Activity ≤ 1 µM, 86 Tested
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
RET G810R Mutant Assay from US Patent US11648243: "Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors"
Assay data:465 Active, 386 Activity ≤ 1 µM, 484 Tested
RET Enzyme Assay from US Patent US11648243: "Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors"
Assay data:814 Active, 808 Activity ≤ 1 µM, 814 Tested
RET Enzyme Assay from US Patent US11603374: "Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors"
Assay data:34 Active, 13 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 34 Tested
Enzyme Assay from US Patent US11548896: "Heterocyclic compounds as RET kinase inhibitors"
Assay data:108 Active, 107 Activity ≤ 1 µM, 109 Tested
IC50 Kinase Assays from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:50 Active, 8 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 50 Tested
HotSpot Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:30 Active, 6 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Selectivity interaction (Enzyme panel (Invitrogen, kinases, and other enzymes)) EUB0000749a RET
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (SelectScreen (Invitrogen)) EUB0000679a RET
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Kinase panel (literature or Upstate/Millipore)) EUB0000665a RET
Inhibition of RET (unknown origin) at 1 uM in presence of ATP by Z'-LYTE assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RET (unknown origin)
Inhibition of full-length RET kinase expressed in human HEK293 cells and measured by NanoBRET assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human RET kinase using IGF1Rtide as substrate incubated for 40 mins and measured by ADP-Glo assay
Assay data:24 Active, 19 Activity ≤ 1 µM, 31 Tested
Assay data:3 Tested
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