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Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 to 80 mV holding potential by manual voltage clamp electrophysiology method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells at -65 mV holding potential by Qpatch clamp electrophysiology method
Assay data:5 Active, 5 Tested
Inhibition of recombinant human Nav 1.7 expressed in HEK293F cells incubated for 3 mins by FRET based membrane potential assay
Assay data:43 Active, 20 Activity ≤ 1 µM, 49 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recording
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Nav1.7 (unknown origin) in half-inactivated condition at 1 uM by whole cell patch clamp electrophysiology relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Nav1.7 (unknown origin) in resting condition at 1 uM by whole cell patch clamp electrophysiology relative to control
Inhibition of Nav1.7 (unknown origin) in half-inactivated condition at 30 uM by whole cell patch clamp electrophysiology relative to control
Inhibition of Nav1.7 (unknown origin) in resting condition at 30 uM by whole cell patch clamp electrophysiology relative to control
Inhibition of human Nav1.7 expressed in HEK293 cells assessed as fold change incubated for 1 hr in presence of BSA by sodium influx assay
Assay data:17 Tested
Inhibition of full length human Nav1.7 expressed in HEK cells by whole cell voltage clamp analysis
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 1 hr in presence of veratridine by sodium influx assay
Assay data:16 Active, 15 Activity ≤ 1 µM, 17 Tested
Displacement of [3H]GX-545 Nav1.7 (unknown origin) expressed in HEK cells by liquid scintillation counting based radioligand competition assay
Assay data:17 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 17 Tested
Na+ channel (site 2) CEREP ligand profiling
SummaryRelated BioAssays by Target
NA+/SITE2ATG Eurofins-Panlabs selectivity data (BI)
NA+/SITE2AG Eurofins-Panlabs selectivity data (BI)
Na+ channel CEREP ligand profiling
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