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Rat CRF2 receptor (Corticotropin-releasing factor receptors)
Assay data:9 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at CRF-R2 beta in rat A7r5 cells assessed as inhibition of rat Ucn1 induced cAMP accumulation after 30 mins by radioimmunoassay
Assay data:6 Active, 6 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of corticotropin releasing factor stimulated adrenocorticotropic hormone release from rat pituitary cells
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of corticotropin releasing factor stimulated cAMP production in rat pituitary assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of CRF-stimulated ACTH release in primary rat anterior pituitary cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of corticotropin releasing factor-induced ACTH release from rat pituitary cells
Binding affinity at corticotropin releasing hormone receptor in rat frontal cortex homogenates by [125I]Tyr-o-CRF displacement.
Assay data:17 Active, 11 Activity ≤ 1 µM, 18 Tested
Compound was tested for the binding affinity to rat corticotropin releasing factor receptor
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Tested in vitro to antagonize CRF-induced release of ACTH by rat pituitary cells in culture
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vitro ability (peptide) to stimulate ACTH release by rat anterior pituitary cells relative to Ovine corticotropin releasing factor (oCRF).
Assay data:27 Tested
Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)
Assay data:1 Tested
Compound was evaluated for affinity towards Corticotropin releasing factor receptor 2 expressing tissues such as Choroid plexus, blood vessels
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of binding of the radioligand, [125 I-Tyr0]-CRF to rat cerebral cortex membrane
Assay data:1 Active, 1 Tested
In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
In vitro binding affinity to the CRF receptor in rat cortical homogenates
Assay data:29 Active, 11 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
In vitro binding affinity against CRF receptor (alpha-helical) in rat cortical homogenates
In vitro binding affinity against CRF receptor in rat cortical homogenates
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Compound was tested for the binding affinity to rat ccorticotropin releasing factor receptor
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