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Inhibition of ALK3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BMPR1A (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human GST tagged ALK3 incubated for 30 mins in presence of ATP by QSSA Kit method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Inhibition of human wild type partial length BMPR1A (Q214 to I532 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
Assay data:23 Active, 13 Activity ≤ 1 µM, 28 Tested
Inhibition of human recombinant ALK3 (198 to 525 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
Inhibition of GST-tagged human recombinant ALK3 expressed in insect cells using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 1 hrs by HTRF assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Binding affinity to wild type ALK3 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Inhibition of wild type ALK3 (unknown origin) assessed as enzymatic activity using chemiluminescent substrate by ADP-Glo assay
BMPR1A DiscoveRx kinase panel
SummaryRelated BioAssays by Target
Inhibition of ALK3 (unknown origin) at 1 uM
Luminescence-Based ADPGlo Kinase Activity Assay from US Patent US11160797: "Pyridinone derivatives and their use as selective ALK-2 inhibitors"
Assay data:48 Active, 43 Activity ≤ 1 µM, 48 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ADPGlo Assay from US Patent US10947218: "Aminopyridine derivatives and their use as selective ALK-2 inhibitors"
Assay data:87 Active, 86 Activity ≤ 1 µM, 87 Tested
ADPGlo Assay from US Patent US10710980: "Aminopyridine derivatives and their use as selective ALK-2 inhibitors"
Assay data:88 Active, 87 Activity ≤ 1 µM, 88 Tested
In Vitro Kinase Assay from US Patent US10501436: "Compounds and methods of use"
Biochemical Binding Assay from US Patent US9469613: "(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide"
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