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Inhibition of ACAT in human THP-1
Assay data:4 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryRelated BioAssays by Target
Inhibition of SOAT1 (unknown origin) expressed in CHO cells using [14C]oleic acid incubated for 6 hrs
Assay data:10 Active, 21 Tested
Inhibition of SOAT1 (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of SOAT1 (unknown origin) expressed in CHO cells using [1-14C]oleic acid as substrate measured after 6 hrs
Assay data:1 Tested
Inhibition of human SOAT1 expressed in mouse AC29 cells
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of human SOAT1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition Assay from US Patent US9149492: "Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease"
Assay data:8 Active, 8 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ACAT-1 Enzyme Inhibition Assay from Article 10.1021/jm801507v: "Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor."
Assay data:1 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Effect on ACAT2 Activity from US Patent US10278962: "Tricyclic analogues, preparation method and uses thereof"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of human SOAT1-mediated [14C]Cholesterol ester biosynthesis in CHO microsomal fraction after 5 mins in presence of [1-14C]oleoyl-CoA by TLC analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human SOAT1 mediated [14C]Cholesterol ester synthesis in CHO cells after 6 hrs in presence of [14C]Oleic acid by TLC analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ACAT1 in human HepG2 cells using cholesterol as substrate incubated for 9 hrs by fluorescence based cholesterol oxidase assay
Assay data:6 Tested
Inhibition of human ACAT1
Assay data:16 Active, 6 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:1 Active, 6 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholesterol by cholesterol E-test analysis
Assay data:21 Active, 17 Activity ≤ 1 µM, 21 Tested
Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic acid/sodium oleate addition measured after 2 hrs in absence of albumin by TLC assay
Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic acid/BSA/sodium oleate addition measured after 2 hrs by TLC assay
Assay data:1 Active, 1 Tested
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