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Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000713a STK10
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000713a STK10
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000713a STK10
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000703a STK10
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a STK10
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b STK10
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a STK10
Thermal Shift Assay. Domain: start/stop: R18-E317
Assay data:27 Tested
Binding affinity to LOK (unknown origin) assessed as dissociation constant by competition binding assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
LOK DiscoveRx kinase panel
STK10 SGC Tm panel (DSF)
LOK(h) Kinase panel
Inhibition of LOK (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of wild-type human partial length LOK (E16 to V314 residues) expressed in bacterial expression system assessed as residual activity at 500 nM by Kinomescan method relative to control
Assay data:2 Tested
Inhibition of human recombinant LOK assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
Kinase Screen Assay from US Patent US8765747: "Fused 2-aminothiazole compounds"
Fluorescence Assay from Article 10.1021/cb300623a: "A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
KinomeScan assay: inhibition of LOK
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
LOK(h) Eurofins kinase panel
NanoBRET assay (SGC) with STK10
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