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Inhibition of TIE2 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TIE2 (unknown origin) at 1 uM relative to control
Inhibition of human recombinant GST-fused TIE2 expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Active, 2 Tested
Inhibition of TIE2 (unknown origin) assessed as dissociation constant
Assay data:3 Tested
Inhibition of TIE2 (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
Inhibition of Tie2 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
D3R2025 from Article : "Drug Design Data Resource Grand Challenge 3 Dataset: TIE2"
Assay data:8 Active, 6 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Kinase panel (activity or binding assay)) EUB0000674a TEK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a TEK
Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000713a TEK
Affinity Biochemical interaction (KdELECT (DiscoverX)) EUB0000703a TEK
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000713a TEK
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000703a TEK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Cell-based TEK autophosphorylation assay in HUVEC cells) EUB0000713a TEK
Inhibition human wild type partial length Tie2 (N804 to T1112 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by Kinomescan method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition human wild type partial length Tie2 (N804 to T1112 residues) expressed in bacterial expression system by Kinomescan method
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant full length Tie-2 in presence of ATP by alphascreen assay
Inhibition of Tie-2 (unknown origin) by HTRF assay
Inhibition of full length C-terminal nanoLuc-tagged human TIE2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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