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Displacement of [125I]-T4 from human recombinant TTR expressed in Escherichia coli BL21(DE3) Star by gamma spectrometric analysis
Assay data:16 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human TTR incubated for 20 mins by fluorescence polarization assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human serum TTR assessed as target occupancy incubated for 6 hrs by fluorescence polarization assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of urea-induced Transthyretin denaturation in human plasma preincubated for 1 hr followed by urea addition by Western blot analysis
Assay data:2 Active, 5 Tested
Inhibition of Transthyretin V30M mutant (unknown origin) assessed as acid mediated fibril formation at 1.8 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:5 Tested
Inhibition of Transthyretin V30M mutant (unknown origin) assessed as acid mediated fibril formation at 3.6 uM measured after 72 hrs by UV-vis spectrophotometry
Inhibition of wild-type Transthyretin (unknown origin) expressed in Escherichia coli expression system assessed as acid mediated fibril formation at 3.6 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:9 Tested
Inhibition of wild-type Transthyretin (unknown origin) expressed in Escherichia coli expression system assessed as acid mediated fibril formation at 7.2 uM measured after 72 hrs by UV-vis spectrophotometry
Assay data:10 Tested
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as change in entropy by ITC analysis
Assay data:1 Tested
Binding affinity to first binding site of wild type TTR (unknown origin) assessed as change in entropy by ITC analysis
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as change in enthalpy by ITC analysis
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysis
Binding affinity to first binding site of wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysis
Binding affinity to second binding site of wild type TTR (unknown origin) assessed as dissociation constant by ITC assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Stabilization of wild type TTR (unknown origin) assessed as reduction in urea induced unfolding incubated for 30 mins
Assay data:2 Tested
Stabilization of TTR in human plasma assessed as fold increase at 30 to 60 uM relative to tolcapone
Assay data:1 Active, 1 Tested
Displacement of [125I]-T4 binding from human plasma TTR at 39 uM measured after 1 hr by PAGE analysis
Stabilization of recombinant wild type TTR (unknown origin) expressed in Escherichia coli at 30 to 60 uM incubated overnight by IEF assay
Anti-aggregation activity against wild type TTR (unknown origin) assessed as reduction in amyloid formation at 1:1 TTR to compound ratio measured after 30 mins followed by pH decrease and measured after 72 hrs by turbidity based analysis
Assay data:3 Tested
Anti-aggregation activity against wild type TTR (unknown origin) assessed as decrease in aggregation level at 20 uM measured after 30 mins followed by pH decrease and measured after 72 hrs by fluorescent based spectrophotometric analysis
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