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In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:33 Active, 28 Activity ≤ 1 µM, 34 Tested
SummaryRelated BioAssays by Target
Inhibition of TYK2 (unknown origin) at 1 uM relative to control
Assay data:1 Tested
Inhibition of TYK2 dependent IFNalpha-stimulated STAT3 phosphorylation in human Jurkat cells
Assay data:22 Active, 2 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
Binding affinity to TYK2 JH2 domain (unknown origin) assessed as melting temperature at 1 uM by thermal shift assay
Assay data:22 Tested
Binding affinity to TYK2 JH2 domain (unknown origin) assessed as melting temperature at 10 uM by thermal shift assay
Inhibition of TYK2 (unknown origin) at 10 uM by DiscoverX KINOMEscan relative to control
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of TYK2 (unknown origin) by Ambit kinase assay
Assay data:4 Tested
Inhibition of TYK2 (0 to 887 residues) (unknown origin) by Ambit kinase assay
Assay data:3 Tested
Inhibition of GST-fused Tyk2 (888 to 1187 residues) (unknown origin) using FITC-AhxKKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by IFN alpha stimulation for 15 mins by flow cytometry method
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
Inhibition of TYK2 (unknown origin)
Inhibition of TYK2 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Competitive inhibition of TYK2 (unknown origin) in the presence of ATP by JAK radiometric filter binding kinase assay
Inhibition of human TYK2 kinase domain incubated for 1 hrs in the presence of ATP by spectrophotometric analysis
Inhibition of recombinant TYK2 (unknown origin) in the presence of ATP
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of recombinant human TYK2 (870 to 1187 residues)
Inhibition of recombinant human TYK2 (871 to end residues) in the presence of [gamma p33]-ATP
Inhibition of N-terminal flag tagged human TYK2 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the presence of [gamma p33]-ATP by FRET assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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