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Inhibition of WEE1 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assay
Assay data:42 Active, 36 Activity ≤ 1 µM, 42 Tested
Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assay
Assay data:49 Active, 47 Activity ≤ 1 µM, 49 Tested
Inhibition of Wee1 in human MV4-11 cells assessed as reduction in phosphorylation of CDK1-Y15 incubated for 24 hrs by Western blot analysis
Inhibition of recombinant human Wee1 (214 to end residues) incubated for 1 hr in presence of tracer 178 by fluorescence based assay
Assay data:40 Active, 39 Activity ≤ 1 µM, 40 Tested
Binding affinity to Wee1 (unknown origin) assessed as dissociation constant
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human full length N-terminal GST tagged Wee1 expressed in E coli
Inhibition of recombinant Wee1 (unknown origin) by TR-FRET assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of recombinant Wee1 (unknown origin) incubated for 1 hr by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human Wee1 incubated for 30 mins by liquid scintillation counter method
Inhibition of Wee1 (unknown origin)
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
Inhibition of Wee1 (unknown origin) incubated for 60 mins by LanthaScreen Eu-Kinase binding assay
Assay data:23 Active, 14 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation at 1 uM measured after 24 to 48 hrs by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at CRBN/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at VHL/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human BT-549 cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at VHL/Wee1 in human BT-549 cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human MCF7 cells assessed as induction of Wee1 degradation at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
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