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SelectScreen Biochemical Kinase Assay from Article 10.1074/jbc.M113.507525: "Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PI3Kbeta in mouse NIH/3T3 cells assessed as reduction in LPA-stimulated AKT S473 phosphorylation up to 3 uM incubated for 1 hr by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length recombinant mouse PI3K p110beta/p85alpha at 1 uM relative to control
Inhibition of full length recombinant mouse PI3K p110beta/p85beta at 1 uM relative to control
Inhibition of recombinant full-length mouse p110b/p85b at 1 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting method
Inhibition of recombinant full-length mouse p110b/p85a at 1 uM using phosphatidylinositol 4,5-bisphosphate as substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting method
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
TLR-pathway-mouse_LPS ligand_TNF readout
Assay data:130 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
TLR-pathway-mouse_P3C ligand_TNF readout
Assay data:115 Active, 756 Tested
TLR-pathway-mouse_LPS ligand_NFkB readout
Assay data:137 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_NFkB readout
Assay data:147 Active, 756 Tested
TLR-pathway-mouse_R848 ligand_TNF readout
TLR-pathway-mouse_P3C ligand_NFkB readout
Assay data:128 Active, 756 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Secondary Screen
Assay data:207 Active, 1576 Tested
SummaryPubMed Citation
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
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