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Disruption of microtubule network in human A549 cells at 600 nM measured after 24 hrs by immunofluorescence staining assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of colchicine binding to tubulin (unknown origin) at 2 to 16 uM by competitive binding assay
Inhibition of tubulin polymerization (unknown origin) incubated for 30 mins in presence of GTP by spectrophotometric analysis
Inhibition of tubulin polymerization (unknown origin) incubated for 15 mins in presence of GTP by fluorescence-based tubulin polymerization assay kit
Assay data:7 Active, 8 Tested
Binding affinity to tubulin (unknown origin) using podophyllotoxin by Competition assay
Binding affinity to tubulin (unknown origin) assessed as fluorescence peak around 460 nm by UV/vis absorption spectroscopy
Inhibition of tubulin (unknown origin) assembly measured at 5 uM by fluorescence assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to microtubule polymerization (unknown origin) assessed as formation of microtubule at 27.5 uM measured for 2 hrs by plate reader method
Assay data:4 Active, 4 Tested
Induction of microtubule disruption in human HeLa cells assessed as loss of formation of cell membrane rounding measured after 24 hrs at 2 to 5 nM by DAPI staining based laser scanning confocal microscopic analysis
Induction of microtubule disruption in human HeLa cells assessed as loss of cellular structure measured after 24 hrs at 2 to 5 nM by DAPI staining based laser scanning confocal microscopic analysis
Binding affinity to beta-tubulin colchicine binding site in human HeLa cells assessed as inhibition of EBI-beta-tubulin adduct formation measured at 5 to 25 uM incubated for 2 hrs followed by addition of EBI measured after 1.5 hrs by EBI competition based Western blotting analysis
Induction of microtubule disruption in human HeLa cells assessed as loss of formation of cell membrane rounding at 0.1 to 0.2 uM measured after 24 hrs by DAPI staining based laser scanning confocal microscopic analysis
Induction of microtubule disruption in human HeLa cells assessed as loss of cellular structure at 0.1 to 0.2 uM measured after 24 hrs by DAPI staining based laser scanning confocal microscopic analysis
Inhibition of tubulin polymerization (unknown origin) by microplate reader analysis
Induction of microtubule disruption in human A549 cells assessed as abnormal chromosomes at 5 to 20 uM incubated for 12 hrs by immunofluorescence based laser scanning confocal microscopic analysis
Induction of microtubule disruption in human A549 cells assessed as abnormal uncondensed cytoplasm at 5 to 20 uM incubated for 12 hrs by immunofluorescence based laser scanning confocal microscopic analysis
Induction of microtubule disruption in human A549 cells assessed as punctate disorder formation at 5 to 20 uM incubated for 12 hrs by immunofluorescence based laser scanning confocal microscopic analysis
Induction of microtubule disruption in human A549 cells assessed as shrunken spindle shaped microtubule structure at 5 to 20 uM incubated for 12 hrs by immunofluorescence based laser scanning confocal microscopic analysis
Inhibition of [3H]colchicine binding to tubulin (unknown origin) by competitive binding assay
Assay data:3 Active, 3 Tested
Inhibition of [3H]colchicine binding to tubulin (unknown origin) at 10 uM by competitive binding assay relative to control
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