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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000343a PIP4K2C
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000336a PIP4K2C
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000169b PIP4K2C
Selectivity interaction (ActivX KiNative profiling assay (in HCT-116 cell line (CRL-1619))) EUB0000642a PIP4K2C
Assay data:1 Active, 1 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000178b PIP4K2C
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000178b PIP4K2C
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human wild type full length PIP5K2C (M1 to A421 residues) expressed in mammalian expression system assessed as remaining activity at 1 uM by Kinomescan assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
PIP5K2C DiscoveRx kinase panel
Inhibition of PI5P4Kgamma (unknown origin) at 1 uM by KINOMEscan analysis
Assay data:3 Tested
Inhibition of GST-fused human recombinant PI5P4Kgamma expressed in Escherichia coli BL21 (DE3) using dipalmitoyl-PI5P and [gamma-32P]ATP as substrate incubated for 10 to 60 mins by radiometric 32P-ATP/PI5P incorporation assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to PI5P4Kgamma (unknown origin) by KINOMEscan analysis
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to ePL-tagged wild type PI5P4Kgamma (unknown origin) expressed in HEK293 cells incubated for 60 mins by InCell pulse thermal stabilization assay
Assay data:7 Active, 4 Activity ≤ 1 µM, 12 Tested
Binding affinity to PI5P4Kgamma (unknown origin) assessed as change in melting temperature at 63 uM by thermal shift assay
Assay data:27 Tested
KinomeScan assay: inhibition of PIP5K2C
Assay data:2 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of wild-type human partial length PIP5K2C (M1 to A421 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Inhibition of human PIP5K2C assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human PIP5K2C assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human PIP5K2C assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of PIP4K2C in human NCI-H929 cells at 10 uM by mass spectroscopic analysis relative to control
Assay data:6 Tested
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