BioAssay by Target (List) for Gene (Select 8242) - PubChem BioAssay - NCBI

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Select item 19340541.

Inhibition of KDM5C (unknown origin ) by Alphalisa analysis

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934054

Summary Related BioAssays by Target

Select item 19340482.

Inhibition of KDM5C (unknown origin ) demethylase activity using H3 as substrate by Chemiluminescent assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Tested

AID:: 1934048

Summary Related BioAssays by Target

Select item 19340433.

Inhibition of KDM5C (unknown origin ) by Cellular luciferase reporter assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Tested

AID:: 1934043

Summary Related BioAssays by Target

Select item 19340404.

Inhibition of KDM5C (unknown origin ) by TR-FRET assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1934040

Summary Related BioAssays by Target

Select item 19340315.

Inhibition of KDM5C (unknown origin ) by HTMS assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1934031

Summary Related BioAssays by Target

Select item 19340246.

Inhibition of KDM5C (unknown origin ) by Alphascreen assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:8 Active, 4 Activity ≤ 1 µM, 9 Tested

AID:: 1934024

Summary Related BioAssays by Target

Select item 19340217.

Inhibition of N-terminal his6-tagged human KDM5C (1 to 839 residues) expressed in sf9 insect cells incubated for 20 mins by Alphascreen assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1934021

Summary Related BioAssays by Target

Select item 19282008.

Inhibition of KDM5C (unknown origin)

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1928200

Summary Related BioAssays by Target

Select item 19165699.

Inhibition of KDM5C (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1916569

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188533410.

Inhibition of KDM5C (unknown origin) in presence of 300 uM 2-OG

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1885334

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188533311.

Inhibition of KDM5C (unknown origin) in presence of 4 uM 2-OG

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1885333

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188526812.

Inhibition of KDM5C (unknown origin) measured by by cell imaging assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Tested

AID:: 1885268

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 188526613.

Inhibition of KDM5C (unknown origin) measured by RapidFire mass spectrometry (RFMS)

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1885266

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187246714.

Inhibition of KDM5C (unknown origin)

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Tested

AID:: 1872467

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187246315.

Inhibition of N-terminal FLAG/His-tagged full-length human KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using peptide substrate at 10 uM incubated for 2 hrs by Alpha Screen assay relative to control

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Tested

AID:: 1872463

Summary PubMed Citation Related BioAssays by Target

Select item 187246216.

Inhibition of N-terminal FLAG/His-tagged full-length human KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using peptide substrate incubated for 2 hrs by Alpha Screen assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1872462

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185660317.

Inhibition of KDM5C (unknown origin) incubated for 30 mins by HRTF assay

Source:: ChEMBL

Protein Target:: Lysine-specific demethylase 5C

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1856603

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180266018.

AlphaScreen Assay from Article 10.1016/j.chembiol.2017.02.006: "Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells."

Source:: BindingDB

Protein Targets:: Histone lysine demethylase PHF8; ...
Total:: 12

Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested

AID:: 1802660

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 180199219.

Demethylase AlphaScreen Assay from Article 10.1038/nchembio.2087: "Structural analysis of human KDM5B guides histone demethylase inhibitor development."

Source:: BindingDB

Protein Targets:: Lysine-specific demethylase 3A; ...
Total:: 8

Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1801992

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180198920.

KDM5 TR-FRET Assay from Article 10.1038/nchembio.2085: "An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells."

Source:: BindingDB

Protein Targets:: Lysine-specific demethylase 5A; ...
Total:: 3

Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1801989

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (33)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (29)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (45)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (53)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (53)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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