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Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a RIOK1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a RIOK1
Thermal Shift Assay. Domain: start/stop: E143-T494
Binding affinity to RIOK1 in human MKN-1 cells assessed as negative shift in melting temperature at 5 uM incubated for 3 hrs followed by heat treatment at 52 to 62 degC for 3 mins by CETSA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by KINOMEscan assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human wild type full length RIOK1 (M1 to E519 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
Inhibition of human wild type full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system assessed as remaining activity at 1 uM relative to control
RIOK1 DiscoveRx kinase panel
RIOK1 SGC Tm panel (DSF)
Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system assessed as residual binding level at 100 nM by Kinomescan method relative to control
KinomeScan assay: inhibition of RIOK1
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Inhibition of human RIOK1 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Inhibition of DNA-tagged human RIOK1 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of human RIOK1 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system assessed as residual activity at 1 uM by kinomescan assay
Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system by Kinomescan method
Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control
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