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Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryRelated BioAssays by Target
Inhibition of caspase-7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of caspase-3/7 activity in human 518A2 cells at 25 nM preincubated for 24 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of caspase-3/7 activity in human 518A2 cells at 1 uM preincubated for 6 hrs followed by caspase-3/7 fluorogenic substrate addition and measured after 60 mins by fluorescence assay
Assay data:1 Active, 1 Tested
Activation of caspase 3/7 in human MV4-11 cells incubated for 6 hrs by Caspase-Glo 3/7 reagent based microplate reader analysis
Assay data:32 Active, 27 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Procaspase-7 Activation Assay from Article 10.1038/nchembio814: "Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy."
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/jm900135r: "Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6."
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2003.10.064: "Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2005.05.116: "Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors."
Assay data:29 Active, 26 Activity ≤ 1 µM, 29 Tested
In Vitro Inhibitory Activity of Caspase from US Patent US10167313: "Selective caspase inhibitors and uses thereof"
Assay data:18 Active, 17 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Caspase Inhibition Assay from Article 10.1021/jm0506625: "N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies."
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Caspase Inhibition Assay from Article 10.1021/jm050896o: "Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors."
Assay data:51 Active, 49 Activity ≤ 1 µM, 51 Tested
Enzyme Inhibition Assay from Article 10.1021/jm0493212: "Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach."
Assay data:1 Active, 11 Tested
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
Peptidase, CASP7 (Caspase 7) Eurofins-Panlabs enzyme assay
Assay data:2 Tested
Caspase-7 (h) Eurofins-Cerep enzyme and uptake assay
Assay data:1 Tested
CASPASE-7(H) Eurofins SafetyScreen44 (BI)
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