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Agonistic Activity Assay from US Patent US9253997: "Alkylamine derivative"
Assay data:30 Active, 15 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Calcium-Sensing Receptor Antagonist Fluorescence Assay from Article 10.1021/jm801178c: "Discovery and Structure-Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists."
Assay data:30 Active, 21 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (CASR)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human CaSR in human HEK293 cells measured after 5 mins by FLIPR assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluorescence assay
Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested
Binding affinity to human CaSR expressed in HEK293 cells after 30 mins in presence of NPS 568 by liquid scintillation counting method
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay
Assay data:20 Active, 18 Activity ≤ 1 µM, 20 Tested
Inhibition of human calcium sensing receptor expressed in HEK293 cells assessed as decrease in calcium flux at 10 uM by fluorometric method relative to control
Human CaS receptor (Calcium-sensing receptor)
Assay data:17 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at calcium sensing receptor (unknown origin) by cell based FLIPR assay
Assay data:20 Active, 19 Activity ≤ 1 µM, 21 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Activation of human CaSR
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
Positive allosteric modulation of human CaSR expressed in CHO cells assessed as increase in intracellular calcium level after 5 hrs by luciferase reporter gene assay
Assay data:31 Active, 30 Activity ≤ 1 µM, 31 Tested
Ratio of R-568 EC50 to compound EC50 for positive allosteric modulation of human CaSR
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