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Inhibition of DGAT1 (unknown origin)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human DGAT1 in serum starved HEK293 cells assessed as inhibition of triglyceride synthesis incubated for 20 mins followed by 13C-addition of 13C-oleic acid pre-complexed with BSA for 120 mins by LC-MS-based mass spectrophotometric analysis
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human DGAT1 using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US10709718: "Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Assay from US Patent US10385066: "Compounds as diacylglycerol acyltransferase inhibitors"
Assay data:35 Active, 2 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested
Enzyme Inhibition Assay from US Patent US9321728: "Beta-alanine derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical composition comprising same as active ingredient"
Assay data:33 Active, 33 Activity ≤ 1 µM, 33 Tested
DGAT1 Inhibitory Assay from US Patent US9302996: "Continuous arycyclic compound"
Assay data:145 Active, 9 Activity ≤ 1 nM, 145 Activity ≤ 1 µM, 145 Tested
PMSA Inhibition Assay from US Patent US9296708: "Chimeric small molecules for the recruitment of antibodies to cancer cells"
Assay data:17 Active, 10 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition Assay from US Patent US9271969: "Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme"
Assay data:67 Active, 8 Activity ≤ 1 nM, 67 Activity ≤ 1 µM, 67 Tested
Inhibition Assay from US Patent US9108956: "Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from US Patent US8912208: "(4-{4-[5-(benzooxazol-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid useful for treating or preventing conditions or disorders associated with DGAT1 activity"
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from US Patent US8703761: "Organic compounds"
Assay data:15 Active, 10 Activity ≤ 1 µM, 15 Tested
Biological Assay from US Patent US8637507: "Bicyclic compounds as inhibitors of diacylglycerol acyltransferase"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Measurement of DGAT1 Inhibitory Activity from US Patent US10308636: "Aromatic heterocyclic compound"
Assay data:80 Active, 2 Activity ≤ 1 nM, 80 Activity ≤ 1 µM, 80 Tested
DGAT Enzyme Inhibition Assay from Article 10.1021/jm801507v: "Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor."
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro FlashPlate Assay from Article 10.1021/jm7013887: "Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor."
Lipid Extraction (LE) Assay from US Patent US9796729: "Compounds as diacylglycerol acyltransferase inhibitors"
Assay data:33 Active, 2 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 33 Tested
LE Assay from US Patent US9738658: "Compounds as diacylglycerol acyltransferase inhibitors"
Assay data:36 Active, 2 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
Human DGAT1LE Assay from US Patent US10174049: "Compounds as diacylglycerol acyltransferase inhibitors"
FlashPlate™ Assay from US Patent US9688696: "Piperidine/piperazine derivatives"
Assay data:115 Active, 51 Activity ≤ 1 µM, 115 Tested
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