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CDK1/CyclinB1 Enzyme Reaction System from US Patent US20230303564: "PYRIMIDINE RING COMPOUND"
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of CDK1/cyclin B1 (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant CDK1/CycB1 (unknown origin) using CTD as substrate incubated for 60 mins by Beckman scintillation counter analysis
Protein Serine/Threonine Kinase, cdk1/Cyclin B Eurofins-Panlabs enzyme assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CDK1/cyclinB (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDK1/Cyclin B (unknown origin) in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay
Inhibition of CDK1/Cyclin B (unknown origin) assessed as residual activity at 1 uM in presence of 33P-ATP incubated for 2 hrs by kinase selectivity assay
Inhibition of cdk1/Cyclin B (unknown origin) at 1 uM measured after 1 hr relative to control
Assay data:5 Tested
In Vitro Kinase Inhibition Assay from US Patent US11174252: "Heterocyclic compounds as kinase inhibitors"
Assay data:30 Active, 3 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 30 Tested
In Vitro Kinase Assay from US Patent US10787436: "Inhibitors of cyclin-dependent kinase 7 (CDK7)"
Assay data:38 Active, 37 Activity ≤ 1 µM, 40 Tested
Cell Proliferation Assay from Article 10.1016/j.chembiol.2005.08.008: "A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:6 Active, 5 Activity ≤ 1 µM, 9 Tested
Inhibition Assay from Article 10.1016/j.chembiol.2005.08.008: "A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression."
In Vitro Kinase Assay from Article 10.1016/j.chembiol.2005.08.008: "A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression."
GSK-3beta Kinase Inhibition Assay from Article 10.1016/j.bmc.2009.01.019: "Design, synthesis and structure-activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta."
Assay data:29 Active, 29 Activity ≤ 1 µM, 30 Tested
Kinase SPA Assay from Article 10.1021/jm9006559: "Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor."
Assay data:27 Active, 1 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 27 Tested
CDK Assay from US Patent US10308654: "Preparation and use of kinase inhibitor"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
CDK Inhibition Assay from Article 10.1021/jm801340z: "Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue."
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Aurora Kinase Assay from Article 10.1021/jm800984v: "Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity."
Assay data:13 Active, 12 Activity ≤ 1 µM, 13 Tested
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