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Inhibition of human alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and measured for 1 to 5 days in presence of Ach stimulation by voltage-clamp based electrophysiological method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at rat alpha6/alpha3beta4 nAChR
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at rat alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at 10^-5 M at -70 mV holding potential preincubated for 5 mins followed by Ach stimulation by voltage-clamp based electrophysiological method relative to control
Antagonist activity at rat alpha6/alpha3beta4 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential preincubated for 5 mins followed by Ach stimulation by voltage-clamp based electrophysiological method
Assay data:3 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-electrode voltage-clamp method
Assay data:2 Tested
NACH/H Eurofins SafetyScreen44 (BI)
SummaryRelated BioAssays by Target
Antagonist activity at nAChR in human PC-3 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at nAChR in human HT-29 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at nAChR in human MDA-MB-231 cells assessed as reduction cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 1 to 30 uM incubated for 5 mins by two electrode voltage-clamp assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human alpha6/alpha3beta2beta3 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-electrode voltage-clamp method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human alpha6beta4 nAChR expressed in Xenopus laevis oocytes assessed as recovery of acethylcholine-evoked currents at 10 uM treated for 10 mins followed by compound washout by two-electrode voltage-clamp method relative to control
Assay data:3 Tested
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 10 uM in presence of peIA by two-electrode voltage-clamp method relative to control
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by measuring fold change measured after 5 min by two-electrode voltage-clamp method relative to peIA
Assay data:28 Tested
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured after 5 min by two-electrode voltage-clamp relative to peIA
Assay data:52 Tested
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measured after 5 min by two-electrode voltage-clamp method
Assay data:50 Active, 4 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 53 Tested
Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 10 uM measured after 5 min by two-electrode voltage-clamp method relative to control
Inhibition of neuronal nicotinic receptor (unknown origin) at 0.1 to 1 uM
Inhibition of human nAChR at 10 uM relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
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