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STK17B SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of wild type human DRAK2 in presence of ATP by radiometric kinase assay
Inhibition of wild type human DRAK2 at 1 uM by DiscoverX scanMAX assay relative to control
Thermal Shift Assay. Domain: start/stop: M25-S329
Assay data:27 Tested
Inhibition of DRAK2 (unknown origin) transfected in HEK293T cells using NanoBRET NanoGlo as substrate incubated for 2 hrs by NanoBRET assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to wild type full length human DRAK2 (1 to 372 residues) expressed in bacterial expression system assessed as change in melting temperature by SYPRO orange dye based DSF assay
Assay data:23 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of STK17B (DRAK2) (unknown origin) at 0.1 uM relative to control
Assay data:2 Tested
Inhibition of STK17B (DRAK2) (unknown origin) at 1 uM relative to control
Binding affinity to recombinant STIK17B (unknown origin) assessed as change in melting temperature 10 uM by differential scanning fluorimetry
DRAK2 DiscoveRx kinase panel
DRAK2(h) Kinase panel
Inhibition of full length recombinant human DRAK2 using KKRPQRRYSNVF as substrate at 1 uM incubated for 120 mins in presence of [gamma-33P-ATP] by radiometric scintillation assay relative to control
Assay data:4 Tested
Inhibition of recombinant human DRAK2 using KKRPQRRYSNVF as substrate after 120 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human STK17B assessed as thermal stability by measuring melting temperature at 10 uM by differential scanning fluorimetry
Assay data:6 Tested
Inhibition of wild-type human full length DRAK2 (M1 to C372 residues) expressed in bacterial expression system at 1 uM by Kinomescan method
Activity Inhibition Assay from US Patent US10647686: "Substituted pyrimidines for preventing or treating cancer and inflammatory diseases"
Assay data:50 Active, 48 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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