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RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of PHA-P-induced TLR4 signaling by measuring reduction in IL-8 secretion preincubated for 30 mins followed by PHA-P stimulation measured after overnight incubation by ELISA
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling by measuring reduction in IL-8 secretion preincubated for 30 mins followed by LPS stimulation measured after overnight incubation by ELISA
Binding affinity to CD14/MD2 in human PBMC assessed as inhibition of LPS-induced TLR4 signaling by measuring decrease in IL-8 secretion at 1 to 10 uM preincubated for 30 mins followed by LPS stimulation for 18 hrs by ELISA
Binding affinity to CD14/MD2 in human PBMC assessed as inhibition of LPS-induced TLR4 signaling by measuring decrease in IL-6 secretion at 1 to 10 uM preincubated for 30 mins followed by LPS stimulation for 18 hrs by ELISA
Binding affinity to CD14/MD2 in human PBMC assessed as inhibition of LPS-induced TLR4 signaling by measuring decrease in TNFalpha secretion at 1 to 10 uM preincubated for 30 mins followed by LPS stimulation for 18 hrs by ELISA
Assay data:1 Active, 2 Tested
Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of PHA-P-induced TLR4 signaling preincubated for 30 mins followed by PHA-P stimulation measured after overnight incubation by secreted embryonic alkaline phosphatase reporter gene assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling at 0.1 to 100 uM preincubated for 30 mins followed by LPS stimulation measured after overnight incubation by secreted embryonic alkaline phosphatase reporter gene assay
Assay data:3 Tested
Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling preincubated for 30 mins followed by LPS stimulation measured after overnight incubation by secreted embryonic alkaline phosphatase reporter gene assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
TLR-pathway-human_P3C ligand_TNF readout
Assay data:143 Active, 756 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
TLR-pathway-human_R848 ligand_TNF readout
Assay data:134 Active, 756 Tested
TLR-pathway-human_FLG ligand_TNF readout
Assay data:142 Active, 756 Tested
TLR-pathway-human_LPS ligand_TNF readout
Assay data:140 Active, 756 Tested
TLR-pathway-human_PGN ligand_TNF readout
TLR-pathway-human_P2C ligand_TNF readout
Assay data:130 Active, 756 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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