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Inhibition of MELK (unknown origin) at 1 uM by Adapta assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000332a MELK
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (radiometric kinase assay)) EUB0000677a MELK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: M1-T348
Assay data:27 Tested
Inhibition of MELK (unknown origin) at 0.1 uM relative to control
Inhibition of MELK (unknown origin) at 1 uM relative to control
Inhibition of full length nanoLuc-tagged human MELK expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
Inhibition of human MELK by radiometric PanQinase activity assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human MELK at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Inhibition of MELK (unknown origin) at 1.0 uM relative to control
MELK DiscoveRx kinase panel
MELK SGC Tm panel (DSF)
MELK(h) Kinase panel
Inhibition of MELK (unknown origin) at 1 uM
Inhibition of human recombinant MELK assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
Inhibition of MELK (unknown origin) at 1000 nM relative to control
Characterization of Hits and Compound 15 (MELK-In-1) Derivatives from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MELK Inhibitor Library Screening assay from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:13 Active, 3 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
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