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Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assay
Assay data:36 Active, 6 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysis
Assay data:23 Active, 2 Activity ≤ 1 µM, 53 Tested
Binding affinity to FKBP12 (unknown origin) by NMR analysis
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of mTORC1 in human HeLa cells assessed as inhibition of S6 kinase phosphorylation at T389 at 100 nM after 30 mins by Western blotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Summary
Inhibition of mTORC1 in human COLO205 cells assessed as reduction of 4-EBP1 phosphorylation at 0.1 to 8 uM after 24 hrs by Western blotting
Assay data:3 Active, 3 Tested
Inhibition of mTORC1 in human COLO205 cells assessed as reduction of S6 phosphorylation at 0.1 to 8 uM after 24 hrs by Western blotting
Inhibition of mTORC1 in human SK-HEP1 cells assessed as reduction of 4-EBP1 phosphorylation at 0.1 to 8 uM after 24 hrs by Western blotting
Inhibition of mTORC1 in human SK-HEP1 cells assessed as reduction of S6 phosphorylation at 0.1 to 8 uM after 24 hrs by Western blotting
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
qHTS assay to identify aromatase inhibitors: Summary
Assay data:379 Active, 10486 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary
Assay data:477 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen
Assay data:467 Active, 55 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS assay to identify aromatase inhibitors - cell viability counter screen
Assay data:702 Active, 1 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify aromatase inhibitors
Assay data:905 Active, 3 Activity ≤ 1 nM, 352 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen
Assay data:371 Active, 94 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line
Assay data:477 Active, 4 Activity ≤ 1 nM, 279 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen
Assay data:376 Active, 208 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway
Assay data:1880 Active, 1 Activity ≤ 1 nM, 235 Activity ≤ 1 µM, 10486 Tested
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