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Biological Assay from US Patent US11584735: "Solid forms of a plasma kallikrein inhibitor and salts thereof"
Assay data:2 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of MMP-1 (unknown origin) at 200 nM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMP-1 (unknown origin) at 10 uM
Assay data:9 Tested
Inhibition of MMP-1 (unknown origin) at 5 uM
Assay data:5 Tested
Inhibition of MMP-1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MMP-1 (unknown origin) using DnpPro-Cha-Gly-Cys(Me)-His-Ala-Lys(Nma)-NH2 as substrate by fluorescence spectroscopy
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP1
SummaryRelated BioAssays by Target
Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP1
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP16
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP1
Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregation at 25 uM measured after 3 hrs by ThT fluorescence assay relative to control
Assay data:12 Tested
Inhibition of amyloid beta (1 to 42 ) (unknown origin) self aggregation measured after 3 hrs by ThT fluorescence assay
Assay data:9 Active, 1 Activity ≤ 1 µM, 12 Tested
Inhibition of amyloid beta (1 to 42) (unknown origin) self aggregation after 24 hrs by thioflavin-T fluorescence method
Inhibition of amyloid beta 42 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM relative to control
Assay data:15 Tested
Inhibition of amyloid beta 42 (unknown origin) at 20 uM relative to control
Assay data:8 Tested
Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay
Assay data:8 Active, 15 Tested
Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay
Assay data:7 Active, 15 Tested
Inhibition of amyloid beta 42 transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay
Assay data:3 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of amyloid beta 40 (unknown origin) assessed as disaggregation of fibrillar amyloid beta 40 incubated for 3 days by ELISA assay
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