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Inhibition of human recombinant GCK (1 to 473 residues) using myelin basic protein as substrate in presence of ATP incubated for 40 mins by radiometric based scintillation method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
GCK(h) Kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of GCK (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Activation of human glucokinase assessed as increase rate of glucose turnover
Assay data:2 Tested
Activation of human glucokinase assessed as decrease in glucose Km
Activation of recombinant mouse full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 12 mM glucose by plate reader analysis relative to control
Activation of recombinant mouse full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 12 mM glucose by plate reader analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 2 mM glucose by plate reader analysis relative to control
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 2 mM glucose by plate reader analysis
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins in presence of 5 mM glucose by plate reader analysis relative to control
Displacement of fluorescent labeled derivative from recombinant human hepatic glucokinase incubated for 30 mins in presence of 12 mM glucose by fluorescent polarization assay
Activation of recombinant full length human liver glucokinase expressed in Escherichia coli assessed as maximal activation incubated for 10 mins by plate reader analysis relative to control
Assay data:26 Tested
Activation of recombinant full length human liver glucokinase expressed in Escherichia coli incubated for 10 mins by plate reader analysis
Assay data:26 Active, 25 Activity ≤ 1 µM, 26 Tested
Activation of recombinant human full length liver glucokinase expressed in Escherichia coli incubated for 10 mins in presence of 5 mM glucose by plate reader analysis
Inhibition of human recombinant GCK assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
In Vitro Activity Assay from US Patent US10633348: "Methods to treat lymphoplasmacytic lymphoma"
Assay data:14 Active, 12 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Glucokinase Activity Assay from US Patent US9527838: "2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment"
Assay data:53 Active, 51 Activity ≤ 1 µM, 54 Tested
Glucokinase-Activating Assay from US Patent US9453038: "Glucokinase activator compounds, compositions containing such compounds, and methods of treatment"
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
Activation Assay from US Patent US9409900: "Compound for increasing kinase active and application thereof"
Assay data:4 Active, 4 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Coupled Enzymatic Assay from US Patent US9340506: "Acetamide derivatives as glucokinase activators, their process and medicinal applications"
Assay data:32 Active, 28 Activity ≤ 1 µM, 34 Tested
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