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Inhibition of mouse cGAS
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of mouse cGAS expressed in RAW-Lucia ISG transfected with HT-DNA assessed as suppression of lipofectamine 2000:ds-DNA complex induced activation of cGAS incubated for 1 hr by Quanti-luc reagent based assay
Assay data:13 Active, 25 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of full length mouse CGAS after 2 hrs by RF-MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to mouse CGAS in presence of dsDNA by isothermal titration calorimetric method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Competitive binding affinity to mouse CGAS using GTP as substrate in presence of dsDNA by isothermal titration calorimetric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Competitive binding affinity to mouse CGAS using ATP as substrate in presence of dsDNA by isothermal titration calorimetric method
Substrate activity at recombinant full-length mouse CGAS expressed in Escherichia coli BL21 (DE3) assessed as cyclic dinucleotide formation by measuring reaction conversion at 1 mM incubated for 16 hrs in presence of ATP by HPLC-UV analysis
Assay data:41 Tested
Substrate activity at recombinant full-length mouse CGAS expressed in Escherichia coli BL21 (DE3) assessed as cyclic dinucleotide formation by measuring reaction conversion at 1 mM incubated for 16 hrs in presence of GTP by HPLC-UV analysis
mouse cGAS chemiluminescence screen
Assay data:241 Active, 161421 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
mouse cGAS RapidFire screen
Assay data:231 Active, 125931 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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