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B1/H Eurofins SafetyScreen44 (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding Assay from US Patent US8912221: "Biaryl amide derivatives"
Assay data:44 Active, 5 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Calcium Flux Assays (hB1 IC50 IMR90) from US Patent US20230271931: "CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR"
Assay data:51 Active, 45 Activity ≤ 1 µM, 51 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Calcium Flux Assays (hB1 IC50 free) from US Patent US20230271931: "CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR"
Assay data:164 Active, 146 Activity ≤ 1 µM, 164 Tested
Bradykinin B1 Eurofins-Panlabs radioligand binding assay
Assay data:5 Tested
Assay data:2 Tested
PRESTO-Tango GPCRome screening (BDKBR1)
B1/H Eurofins-Panlabs selectivity data (BI)
Binding affinity to B1 receptor (unknown origin) 10 umol/L by radioligand binding assay
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]desArg10-KD from human recombinant Bradykinin B1 receptor at 10 uM incubated for 120 mins by scintillation counting analysis relative to control
Displacement of [3H]desArg10-KD from human recombinant Bradykinin B1 receptor expressed in CHO-K1 cells assessed as residual binding level for radioligand at 10 uM incubated for 60 mins by radiometric scintillation analysis relative to control
Inhibition of human B1 bradykinin receptor at 10 uM relative to control
Displacement of [3H]Kallidin(des-Arg10,Leu9) from human recombinant bradykinin B1 receptor expressed in CHOK1 cells at 10 uM after 60 mins by scintillation counting assay relative to control
Activity at human bradykinin B1 receptor up to 10 uM
Displacement of [3H]des-Arg10-BK from human recombinant bradykinin B1 receptor expressed in CHO cells at 10 uM measured after 1 hr relative to control
Assay data:3 Tested
Displacement of [3H]des-Arg10-BK from human recombinant bradykinin B1 receptor expressed in CHO cells at 50 uM measured after 1 hr relative to control
Displacement of [3H]desArg10-KD from recombinant human bradykinin B1 receptor at 10 uM after 120 mins by scintillation counting analysis relative to control
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