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Substrate uptake by the Sodium-Dependent Phosphate Transport Protein 2A (NPT2a, SLC34A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC34A1 cells (PubChem AID: 1794813)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of human NaPi2a (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human NaPi2b expressed in KJMGER8 cells assessed as reduction in H2[33P]O4 uptake incubated for 60 mins by TopCount scintillation counting method
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Inhibition of human NaPi2b at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human NaPi2b stably expressed in CHO-K1 cells assessed as reduction in H2[33P]O4 uptake incubated for 30 mins by liquid scintillation counting method
Assay data:16 Active, 15 Activity ≤ 1 µM, 16 Tested
Inhibition of human NaPi2b
Assay data:15 Active, 20 Activity ≤ 1 µM, 21 Tested
Inhibition of NaPi2b (unknown origin)
Inhibition of human NaPi2b expressed in CHO-K1 cells assessed as reduction in [33P] uptake preincubated with compound for 30 mins followed by [33P]O4 addition and measured after 30 mins by TopCount liquid scintillation counting method
Assay data:14 Active, 12 Activity ≤ 1 µM, 14 Tested
Inhibition of human NaPi2b transfected in human KJMGER8 cells assessed as reduction in H2[33P]O4 uptake incubated for 60 mins by TopCount scintillation counting method
Assay data:18 Active, 15 Activity ≤ 1 µM, 18 Tested
Biological Assays from US Patent US11208400: "Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof"
Assay data:526 Active, 475 Activity ≤ 1 µM, 526 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cell-based assay of NaP2b activity from US Patent US10272079: "NHE3-binding compounds and methods for inhibiting phosphate transport"
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Membrane potential-based assay for SLC34A1 using HEK293 JumpIn SLC34A1 OE cells
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of SLC34A2-ROS1 (unknown origin) expressed in human HCC78 cells assessed as reduction in cell viability
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Potency index, ratio of IC50 for crizotinib to lorlatinib IC50 for SLC34A2-ROS1 (unknown origin) expressed in human HCC78 cells
Inhibition of human Nap2B isoform-A expressed in HEK293 cells assessed as reduction in sodium-dependent 33Pi uptake after 23 mins by TopCount liquid scintillation counting method
Assay data:5 Tested
Inhibition of NaPi2a in human primary proximal tubule cells assessed as reduction in uptake of 33P-radiolabeled Pi incubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation counting method
Assay data:3 Tested
Inhibition of NaPi2a in human primary proximal tubule cells assessed as reduction in uptake of 33P-radiolabeled Pi at 1 uM incubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation counting method relative to control
Inhibition of human NaPi2a expressed in HEK293 cells coexpressing tetracyclin assessed as reduction in uptake of 33P-radiolabeled Pi at 5 mM incubated for 20 to 30 mins prior to substrate addition
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