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Cross screening panel
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Assay data:1 Active, 1 Tested
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
Inhibition of CYP3A4 (unknown origin)
Assay data:3 Tested
Inhibition of CYP3A4 in human liver microsomes incubated for 10 mins in presence of NADPH by LC/MS/MS analysis
Assay data:2 Tested
Time dependent inhibition of CYP3A4 in human liver microsomes assessed as residual activity at 5 uM using midazolam as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Reversible inhibition of CYP3A4 in human liver microsomes assessed as residual activity at 5 uM using midazolam as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP3A4
Assay data:2 Active, 2 Tested
Inhibition of CYP3A4 in human liver microsomes
Assay data:1 Active, 2 Tested
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Induction of CYP3A4 in human hepatocytes
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as reduction in substrate hydroxylation incubated for 30 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate assessed as reduction in substrate hydroxylation incubated for 30 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as reduction in substrate hydroxylation incubated for 5 mins in presence of beta-NADPH measured by LC-MS/MS analysis
Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate assessed as reduction in substrate hydroxylation incubated for 5 mins in presence of beta-NADPH measured by LC-MS/MS analysis
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