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Inhibitory Activity of the Compounds of the Invention Against ROS1, NTRK and ALK and their Drug-Resistant Kinases from US Patent US20240025908: "COMPOUND USED AS KINASE INHIBITOR AND USE THEREOF"
Assay data:29 Active, 14 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ALK Enzymatic Activity Test 2 from US Patent US20230322822: "ARYL PHOSPHOROUS OXIDE COMPOUNDS AND USE THEREOF"
Assay data:9 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
Inhibition of ALK Tyrosine Kinase Activity from US Patent US11517561: "Macrocycle and composition comprising thereof"
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Selectivity interaction (LanthaScreen Eu kinase binding assay) EUB0000169b ALK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000169b ALK
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000169b ALK
Selectivity interaction (KinomScan Ambit) EUB0000622a ALK
Selectivity interaction (Kinase panel (Millipore/Upstate Ltd.) ) EUB0000619a ALK
Selectivity interaction (Enzymatic assay) EUB0000609a ALK
Selectivity interaction (Ambit kinase binding assay panel) EUB0000609a ALK
Affinity Biochemical interaction (Microfluidic mobility shift assay) EUB0000690a ALK
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (ELISA (ALK phosphoryaltion in 3T3-EML4-ALK engineered cell lines)) EUB0000690a ALK
Inhibition of ALK (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ALK R1275Q mutant (unknown origin) at 0.1 uM relative to control
Assay data:2 Tested
Inhibition of ALK C1156Y mutant (unknown origin) at 0.1 uM relative to control
Inhibition of ALK (unknown origin) at 0.1 uM relative to control
Inhibition of ALK F1174L mutant (unknown origin) at 0.1 uM relative to control
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