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Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay))
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a NTRK2
Selectivity interaction (Enzymatic assay) EUB0000624a NTRK2
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a NTRK2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (Radiometric assay (10 M ATP, Reaction Biology)) EUB0000005b NTRK2
Affinity Biochemical interaction (LanthaScreenTM Eu) EUB0000640a NTRK2
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000156b NTRK2
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000005b NTRK2
Affinity Phenotypic Cellular interaction (Cell proliferation assay in TRK fusion?containing KM12 cells) EUB0000640a NTRK2
Inhibition of NTRK2 (TRKB) (unknown origin) at 0.1 uM relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TRKB (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of TrkB receptor in Swiss Webster mouse immature cerebrocortical neuron assessed as phosphorylation of TrkB at Tyr516 residue at 30 nM incubated for 30 mins in presence of NMDAR antagonist MK-801 by western blot analysis
Activation of TrkB receptor in Swiss Webster mouse immature cerebrocortical neuron assessed as phosphorylation of TrkB at Tyr516 residue at 30 nM incubated for 30 mins in presence of VGSC blocker TTX by western blot analysis
Activation of TrkB receptor in Swiss Webster mouse immature cerebrocortical neuron assessed as phosphorylation of TrkB at Tyr516 residue at 30 nM incubated for 30 mins by western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of full length isoform of TrkB receptor (unknown origin) expressed in mouse cerebrocortical neuron assessed as increase in neurite length at 30 nM incubated for 24 hrs by DiI dye based microscopic analysis
Activation of TrkB receptor in Swiss Webster mouse immature cerebrocortical neuron assessed as increase in neurite outgrowth at 30 nM incubated for 24 hrs in the presence of TrkB inhibitor K252a by DiI dye based microscopic analysis
Inhibition of TRKB (unknown origin) by radiometric assay
Inhibition of TRKB (unknown origin) at 1.0 uM relative to control
Inhibition of TRKB (unknown origin) incubated for 40 mins in presence of ATP by HTRF assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of NTRK2 (unknown origin) at 1 uM incubated in presence of ATP by Selectscreen kinase assay
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