Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
In vitro Assay from US Patent US20240018122: "PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS"
Assay data:187 Active, 157 Activity ≤ 1 nM, 186 Activity ≤ 1 µM, 188 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
LanthaScreen Eu Kinase Binding Assay from US Patent US11746103: "ALK-5 inhibitors and uses thereof"
Assay data:8 Active, 56 Activity ≤ 1 µM, 56 Tested
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
TGFβR1 Kinase Inhibition Assay from US Patent US11691981: "Heterocyclic compounds, preparation methods therefor, and methods of uses thereof"
Assay data:79 Active, 76 Activity ≤ 1 µM, 80 Tested
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Enzyme Activity Inhibition from US Patent US11584745: "Aromatic heterocyclic compound, intermediate thereof, preparation method therefor, and pharmaceutical composition and use thereof"
Assay data:14 Active, 13 Activity ≤ 1 µM, 15 Tested
Inhibition of human TGF-beta-R1 using TMB substrate incubated for 2.5 hrs by microplate reader analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000252b TGFBR1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000153b TGFBR1
Affinity Biochemical interaction (Lathascreen (Takeda)) EUB0000312b TGFBR1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Radioactive kinase assay (ACVR1B)) EUB0000312b ACVR1B
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000710a TGFBR1
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000710a ACVR1B
Affinity On-target Cellular interaction (Reporter gene assay) EUB0000312b TGFBR1
Affinity On-target Cellular interaction (Reporter gene assay) EUB0000312b ACVR1B
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000710a TGFBR1
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000710a ACVR1B
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000312b TGFBR1
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Western blot (inhibition of SMAD2/3 phosphorylation)) EUB0000312b ACVR1B
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on