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Inhibition of human Top2-alpha expressed in baculovirus assessed as inhibition of relaxation of supercoiled pBR322 plasmid DNA at 100 uM incubated for 30 mins in presence of ATP by ethidium bromide staining based agarose gel electrophoresis analysis relative to control
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Poison activity at human topoisomerase II-alpha assessed as stabilization of enzyme-DNA cleavage complex by measuring nicked DNA formation at 100 uM after 60 mins by agarose gel electrophoresis method
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human DNA topoisomerase II-alpha relaxation activity at 100 uM incubated for 30 mins by chemiDoc system
Assay data:2 Active, 2 Tested
Inhibition of DNA topoisomerase 2 (unknown origin) at 50 to 100 uM measured by gel electrophoresis method
Assay data:1 Tested
Inhibition of DNA topoisomerase 2 (unknown origin) at 25 uM measured by agar gel electrophoresis relative to control
Assay data:1 Active, 3 Tested
Inhibition of human topoisomerase 2 assessed as reduction in decatenation at 10 uM using kDNA as substrate incubated for 30 mins in presence of ATP by ethidium bromide staining based agarose gel electrophoresis analysis
Assay data:1 Active, 2 Tested
Inhibition of human topoisomerase 2 assessed as reduction in decatenation
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis relative to control
Assay data:6 Tested
Catalytic inhibitor of non-intercalative topoisomerase 2alpha (unknown origin) assessed as formation of linearized DNA at 250 uM measured by cleavage complex assay
Assay data:1 Active, 1 Tested
Catalytic inhibitor of non-intercalative topoisomerase 2alpha (unknown origin) assessed as binding to minor groove at 250 to 500 uM measured by cleavage complex assay
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis relative to control
Assay data:7 Tested
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis (Rvb = 37.5%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis (Rvb = 84.9%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis (Rvb = 77.9%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis (Rvb = 30.6%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM by agarose gel electrophoresis (Rvb = 48.4%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis (Rvb = 81%)
Inhibition of recombinant human topoisomerase 2alpha assessed as relaxation of supercoiled plasmid pBR322 DNA at 100 uM by agarose gel electrophoresis (Rvb = 82.2%)
Inhibition of DNA topoisomerase 2 (unknown origin) assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins measured by agarose gel electrophoresis method
Inhibition of topoisomerase 2alpha (unknown origin) assessed as relaxation of supercoiled plasmid pBR322 DNA at 20 uM relative to control
Assay data:14 Tested
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