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ALK2 HTRF Assay from US Patent US11840546: "Imidazopyridazine compounds and uses thereof"
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Activity Inhibition Test (TGFbetaR1) from US Patent US20230303562: "PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
LanthaScreen Eu Kinase Binding Assay from US Patent US11746103: "ALK-5 inhibitors and uses thereof"
Assay data:8 Active, 56 Activity ≤ 1 µM, 56 Tested
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
Biochemical assay from US Patent US11661426: "Imidazole-containing inhibitors of ALK2 kinase"
Assay data:455 Active, 496 Activity ≤ 1 µM, 496 Tested
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000207b ACVR1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ALK-2 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ALK2 in human HeLa cells assessed as inhibition of SMAD1 phosphorylation
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of ALK2 (unknown origin)
Assay data:28 Active, 26 Activity ≤ 1 µM, 28 Tested
Inhibition of human recombinant ALK2 (172 to 499 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
Inhibition of ALK1 (unknown origin)
Assay data:28 Active, 23 Activity ≤ 1 µM, 29 Tested
Inhibition of GST-tagged human recombinant ALK2 (145 to 509 residues) expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of GST-tagged human recombinant ALK1 expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 1 hrs by HTRF assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for 30 mins by HTRF assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of peptide phosphorylation activity using peptide substrate in presence of ATP and measured after 3 hrs by HTRF assay
Assay data:16 Active, 2 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Binding affinity to wild type ALK1 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to wild type ALK2 (unknown origin) assessed as percent of control at 1 uM by Kinomescan method relative to control
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