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HTRF Assay from US Patent US20240018153: "BENZENESULFONAMIDE DERIVATIVES AND USES THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000549a BMX
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000320b BMX
Selectivity interaction (KinaseProfiler? (Millipore)) EUB0000640a BMX
Selectivity interaction (Z?-LYTE assay) EUB0000638a BMX
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a BMX
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity Phenotypic Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (Promega; growth inhibitory activity in Rec-1 cells)) EUB0000646a BMX
Thermal Shift Assay. Domain: start/stop: K264-H675
Assay data:27 Tested
Inhibition of BMX (unknown origin) at 0.3 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human BMX assessed as residual activity at 30 uM relative to control
Inhibition of recombinant human BMX by radiometric kinase assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BMX (unknown origin) at 0.5 uM assessed as competition rate relative to control
Inhibition of BMX (unknown origin) at 0.5 uM relative to control
Binding affinity to BMX (unknown origin) assessed as dissociation constant by KINOMEscan analysis
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of BMX (unknown origin) assessed as residual activity at 200 nM relative to control
Inhibition of BMX (unknown origin)
Inhibition of N-terminal His6-tagged human full length recombinant BMX expressed in Sf21 insect cells using TSFYGRH as substrate preincubated for 5 mins followed by 33p-labeled ATP addition and measured after 1 hr by thin layer chromatography
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human Bmx assessed as residual activity at 10 uM relative to control
Assay data:3 Tested
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