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MMP Inhibitory Assay from US Patent US11673884: "Matrix metalloproteinase (MMP) inhibitors and methods of use thereof"
Assay data:12 Active, 9 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP12
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP12
Affinity Biochemical interaction (Biochemical assay (inhibition of human macrophage elastase (HME/hMMP-12), addition of 2% BSA)) EUB0000728a MMP12
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Biochemical assay (inhibition of human macrophage elastase (HME/hMMP-12), addition of 2% BSA)) EUB0000725a MMP12
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay
Assay data:29 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human MMP-12 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent analysis
Inhibition of recombinant human MMP-12 by ELISA
Inhibition of human MMP-12 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by susbstrate addition by photon-counter spectrophotometer analysis
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP-12 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assay
Inhibition of recombinant human MMP-12 using peptide substrate by ELISA
Assay data:3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MMP-12 (unknown origin)
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of human recombinant MMP-12 (Leu17 to Cys470 residues) using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as fluorogenic substrate preincubated for 15 mins followed by substrate addition by fluorescence based analysis
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibitory Assay from US Patent US10851089: "Matrix metalloproteinase (MMP) inhibitors and methods of use thereof"
Assay data:24 Active, 12 Activity ≤ 1 µM, 30 Tested
MMP Activity Assay from Article 10.1038/nchembio.2326: "Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11."
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Fluorescence Assay from US Patent US9206139: "Aggrecanase inhibitors"
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MMP12 Inhibition Assay from Article 10.1111/cbdd.12481: "Synthesis of Novel Hybrids Inspired from Bromopyrrole Alkaloids Inhibiting MMP-2 and -12 as Antineoplastic Agents."
Assay data:5 Tested
Inhibition Assay from US Patent US8691753: "Pseudodipeptides as MMP inhibitors"
Assay data:101 Active, 1 Activity ≤ 1 nM, 103 Activity ≤ 1 µM, 103 Tested
Enzyme Assay from Article 10.1074/jbc.M110.139634: "Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation."
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Enzyme Assay from Article 10.1074/jbc.M112.380782: "Simple Pseudo-dipeptides with a P2' Glutamate: A NOVEL INHIBITOR FAMILY OF MATRIX METALLOPROTEASES AND OTHER METZINCINS."
Assay data:12 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
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