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Enzyme Inhibition Assays (Assay 1) from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:52 Active, 26 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Neprilysin Inhibition Assay from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from US Patent US11547687: "Neprilysin inhibitors"
Assay data:59 Active, 25 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant N-terminal 6His-tagged human neprilysin expressed in CHO cells at 300 uM using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate and measured by fluorescence based assay relative to control
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluorescence spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10759813: "Neprilysin inhibitors"
Assay data:220 Active, 110 Activity ≤ 1 nM, 220 Activity ≤ 1 µM, 220 Tested
Enzyme Inhibition Assay from US Patent US10744104: "Neprilysin inhibitors"
Assay data:40 Active, 22 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
In Vitro Inhibiton Assay from US Patent US9163040: "Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Fluorescence Lifetime-Based Assay from US Patent US9006249: "Substituted aminobutyric derivatives as neprilysin inhibitors"
Assay data:13 Active, 4 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
In Vitro Inhibition Assay from US Patent US8877786: "Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors"
Assay data:7 Active, 4 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from Article 10.3109/14756369709035816: "Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position."
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
In Vitro Inhibition of NEP from Article 10.1021/jm0005454: "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)."
Assay data:29 Active, 1 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
Fluorescence Lifetime-Based Assay from US Patent US9603819: "Substituted aminobutyric derivatives as neprilysin inhibitors"
Enzyme Inhibition Assays from US Patent US10130642: "Neprilysin inhibitors"
Assay data:63 Active, 36 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 64 Tested
Enzyme Inhibition Assay from US Patent US9593110: "Neprilysin inhibitors"
Assay data:168 Active, 101 Activity ≤ 1 nM, 168 Activity ≤ 1 µM, 168 Tested
Enzyme NEP Inhibition Assay from US Patent US10123984: "Neprilysin inhibitors"
Assay data:47 Active, 21 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 47 Tested
NEUTRALENDOP Eurofins-Panlabs selectivity data (BI)
Assay data:1 Tested
N_ENDOPEP Cerep selectivity data (BI)
Inhibition of NEP 24.11 (unknown origin) by fluorometric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human NEP using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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