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Inhibition of CD40 in IL-4/anti-CD404 stimulated human PBMC at >10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CD40L (unknown origin)
Ratio of IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in presence of Triton-X 100 to IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in absence of Triton-X 100
Assay data:4 Tested
Inhibition of human Fc-conjugated Mac1/FLAG-tagged biotinylated CD40L protein-protein interaction incubated for 1 hr by ELISA-type assay
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of interaction of CD40 in promoter/enhancer region of aicda-fused Ds-Red reporter transfected human B cells with recombinant human CD40L assessed as reduction in CD40L/IL-4-induced B cell activation by measuring AID expression after 2 days by flow cytometric analysis
Assay data:1 Active, 3 Tested
Inhibition of interaction of CD40 in human B cells with recombinant human CD40L assessed as reduction in CD40L-induced cell proliferation after 48 hrs by BrdU incorporation-based ELISA
Assay data:3 Tested
Inhibition of interaction of CD40 (unknown origin) transfected in HEK Blue cells with recombinant human CD40L assessed as reduction in CD40L-induced NF-kappaB activation after 18 hrs by spectrophotometry based SEAP reporter gene assay
Assay data:1 Active, 4 Tested
Inhibition of human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction incubated for 1 hr by ELISA-type assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of interaction of CD40 in human THP-1 cells with recombinant human CD40L assessed as reduction in CD40L-induced MCH-2 upregulation after 48 hrs by DAPI-staining based flow cytometric analysis
Human CD40 (Immune checkpoint catalytic receptors)
Assay data:2 Active, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant human CD40L:mouse CD8 tail binding to human CD40 at 10 uM by surface plasmon resonance method
Binding affinity to human CD40 by surface plasmon resonance method
Assay data:1 Active, 1 Tested
Inhibition of recombinant human CD40L:mouse CD8 tail binding to human CD40 by surface plasmon resonance method
Assay data:3 Active, 2 Activity ≤ 1 µM, 6 Tested
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