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Inhibition of MDM4/p53 interaction in human SH-SY5Y cells incubated for 10 mins by quantitative immuno-enzymatic assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal TEV/GST-fused human MDM4 (22 to 110 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration microcalorimetry method
Inhibition of GST-tagged MDM4/Biotin-tagged p53 interaction (unknown origin) incubated for 40 mins by TR-FRET assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of MDM4/p53 interaction in human SH-SY5Y cells using TMB as substrate incubated for 10 mins by quantitative immuno-enzymatic assay
Inhibition of human MDM4 by TR-FRET assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of MDM4 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MDM4/p53 interaction in human SH-SY5Y cells preincubated for 10 mins under shaking condition and measured after 1.5 hrs by immuno-enzymatic assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9403827: "Substituted purinone compounds"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9365576: "Pyrrolopyrrolidinone compounds"
Assay data:22 Active, 6 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US9051279: "Substituted isoquinolinones and quinazolinones"
Assay data:90 Active, 1 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 98 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US8969341: "Pyrazolopyrrolidine compounds"
Assay data:133 Active, 5 Activity ≤ 1 nM, 132 Activity ≤ 1 µM, 133 Tested
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US8859586: "Cyclohexyl isoquinolinone compounds"
Assay data:32 Active, 29 Activity ≤ 1 µM, 32 Tested
Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay from US Patent US8815926: "Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases"
Assay data:309 Active, 214 Activity ≤ 1 nM, 308 Activity ≤ 1 µM, 310 Tested
Fluorescence Anisotropy Competition Binding Assay from Article 10.1016/j.bmc.2009.10.032: "N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53."
Assay data:13 Active, 30 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to MDMX (unknown origin) by using FITC-labeled compound by fluorescence polarization assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Displacement of 5'FAM-LTFEHYWAQLTS from human recombinant MDMX (18 to 111 residues) expressed in Escherichia coli BL21 (DE3) cells measured after 30 mins by fluorescence polarization assay
Assay data:27 Active, 56 Tested
Inhibition of p53 protein binding to MDMX (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of MDMX (unknown origin)
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