Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
AKT Kinase Activity Assay from US Patent US20230321108: "UNIT DOSAGE COMPOSITION OF AKT INHIBITOR"
Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Test of AKT Kinase Inhibiting Activity from US Patent US20230286979: "SALT OF DIHYDROPYRIDO[2,3-D]PYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF"
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
pAKT Protocol from US Patent US11492348: "Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways"
Assay data:58 Active, 18 Activity ≤ 1 µM, 96 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Induction of AKT2 degradation in human SW620 cells assessed as reduction in total AKT level at 1 uM measured after 18 hrs by TMT-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of AKT degradation in human SW620 cells assessed as reduction in total AKT level at 1 uM measured after 18 hrs by TMT-MS analysis
Assay data:1 Active, 2 Tested
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM preincubated with 3-(3-(4-(amino(cyclobutyl)methyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM preincubated with proteasome inhibitor, MG132 for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM preincubated with NAE inhibitor, MLN4924 for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM preincubated with VHL E3 ligand, VHL-2 for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM measured after 12 hrs by Western blot analysis relative to control
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM by Western blot analysis
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at 1 uM measured for 1 to 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human PANC-1 cells harboring KRAF mutant assessed as reduction in total AKT level at 100 nM incubated for 24 hrs by Western blot analysis relative to control
Induction of AKT degradation in MS21-resistant human PANC-1 cells harboring KRAF mutant assessed as reduction in total AKT level incubated for 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human PANC-1 cells harboring KRAF mutant assessed as reduction in total AKT level at 1 uM incubated for 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human SK-MEL-239 cells harboring BRAF mutant assessed as reduction in total AKT level at 1 uM incubated for 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human HT-29 cells harboring BRAF/PI3KA mutant assessed as reduction in total AKT level at 1 uM incubated for 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human COLO 205 cells harboring BRAF mutant assessed as reduction in total AKT level at 1 uM incubated for 24 hrs by Western blot analysis
Induction of AKT degradation in MS21-resistant human SW620 cells harboring KRAS/BRAF mutant assessed as reduction in total AKT level at upto 10 uM incubated for 24 hrs by Western blot analysis
Assay data:3 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on