Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Agonist activity at human MT1R stably expressed in HEK293 cells at 1 mM by FlexStation3 Bench-top MultiMode Microplate Reader relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader
Selectivity interaction (CEREP panel (Eurofins, radioligand binding assay, enzymes, GPCRS, transporters, and ion channels)) EUB0000308b MTNR1A
SummaryRelated BioAssays by Target
Selectivity interaction (CEREP panel (receptors, ion channels)) EUB0000222b MTNR1A
Binding affinity to human melatonin MT1 assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes upto 1 uM under dark condition by radioligand based competition binding assay
Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by measuring maximal efficacy after 30 mins under dark condition by cAMP assay relative to control
Assay data:2 Tested
Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested
Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes upto 1 uM in presence of light-activated compounds by radioligand based competition binding assay
Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Agonist activity at human MT1 receptor expressed in HEK293 cells assessed as fold change at 1 mM by Fluo-8 based calcium assay relative to Paeovetiol-D
Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment by measuring maximum activity incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis relative to 2-phenylmelatonin
Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment by measuring maximum activity incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis relative to agomelatine
Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as relative luminescence unit incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
Assay data:3 Tested
Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis
Agonist activity at human MT1 receptor expressed in HEK293 cells by Fluo-8 based calcium assay
Assay data:10 Tested
Agonist activity at human MT1 receptor expressed in HEK293 cells at 1 mM by Fluo-8 based calcium assay relative to control
Assay data:36 Tested
MT1 (ML1A) (h) CEREP ligand profiling
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on