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Enzyme Inhibition Assays (Assay 1) from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:52 Active, 26 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Neprilysin Inhibition Assay from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from US Patent US11547687: "Neprilysin inhibitors"
Assay data:59 Active, 25 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ACE in human MNCs assessed as maximum inhibition using substrate Mca-RPGFSAFK (Dnp)-OH as substrate by fluorescence plate reader assay relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human ACE using Mca-RPGFSAFK (Dnp)- OH as substrate by fluorescence plate reader assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human ACE assessed as maximum inhibition using Mca-RPGFSAFK (Dnp)-OH as substrate by fluorescence plate reader assay relative to control
Inhibition of angiotensin converting enzyme (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of angiotensin-converting enzyme (unknown origin)
Assay data:1 Tested
Inhibition of angiotensin converting enzyme (unknown origin) at 10 uM relative to control
Inhibition of ACE (unknown origin) using hippuryl-histidyl-leucine as substrate pre-incubated with compound for 10 mins followed by substrate addition measured after 60 mins by HPLC analysis
Assay data:1 Active, 2 Tested
ACE(HU_AMTCH400) Eurofins SafetyScreen44 (BI)
SummaryRelated BioAssays by Target
Binding affinity to human recombinant ACE protein assessed as dissociation constant incubated for 15 mins by MTS binding analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant C-terminal 10His-tagged human ACE at 300 uM using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate and measured by fluorescence based assay relative to control
Assay data:2 Tested
Inhibition of recombinant human ACE N-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of recombinant human ACE C-domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by fluorescence spectrophotometric analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Enzyme Inhibition Assay from US Patent US11174219: "Neprilysin inhibitors"
Assay data:7 Active, 5 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from US Patent US10829438: "Neprilysin inhibitors"
Enzyme Assay from US Patent US9212206: "4-Fluoro-Thio-containing inhibitors of APP2, compositions thereof and method of use"
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Enzyme Assay from Article 10.1074/jbc.M110.139634: "Insights from selective non-phosphinic inhibitors of MMP-12 tailored to fit with an S1' loop canonical conformation."
In Vitro Inhibition of NEP from Article 10.1021/jm0005454: "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)."
Assay data:29 Active, 1 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
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