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Cell-Based Assay from US Patent US9334288: "Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents"
Assay data:9 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Activity Assay from US Patent US9334288: "Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents"
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
β-Glucuronidase Assay from Article 10.1016/j.bioorg.2017.05.005: "Synthesis of indole analogs as potent -glucuronidase inhibitors"
Assay data:7 Active, 1 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
β-Glucuronidase Assay from Article 10.1016/j.bioorg.2017.01.015: "Synthesis and in silico studies of novel sulfonamides having oxadiazole ring: As -glucuronidase inhibitors."
Assay data:2 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
β-Glucuronidase Bioassay from Article 10.1016/j.bioorg.2016.07.008: "Synthesis, -glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs."
Assay data:11 Active, 4 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
β-Glucuronidase Activity Assay from US Patent US9617239: "Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase"
Assay data:63 Active, 1 Activity ≤ 1 nM, 60 Activity ≤ 1 µM, 88 Tested
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate pre-incubated for 30 mins followed by substrate addition by absorbance method
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate pre-incubated for 30 mins followed by substrate addition by spectrophotometric method
Assay data:5 Active, 4 Activity ≤ 1 µM, 11 Tested
Inhibition of beta-glucuronidase (unknown origin)
Assay data:1 Active, 1 Tested
Inhibition of beta-glucuronidase (unknown origin) relative to control
Inhibition of beta-glucuronidase (unknown origin) at 1 uM relative to control
Assay data:17 Tested
In-vivo inhibition of beta-glucuronidase in BALB/CJ mouse at 10 ug administered as twice daily
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins by spectrophotometric analysis
Assay data:4 Active, 13 Tested
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins
Assay data:39 Active, 7 Activity ≤ 1 µM, 53 Tested
Inhibition of rat liver beta-glucuronidase
Assay data:4 Tested
In-vivo inhibition of ICR mouse beta-glucuronidase at 60 mg/kg, sc after 10 weeks relative to DMH alone
Assay data:1 Tested
In-vivo inhibition of ICR mouse beta-glucuronidase at 20 mg/kg, sc after 10 weeks relative to DMH alone
Inhibition of beta-glucuronidase (unknown origin) at 1 mM relative to control
Assay data:3 Tested
Inhibition of beta-glucuronidase (unknown origin) at 10 mg/ml relative to control
In vivo inhibition of beta-glucuronidase in OF1 mouse at 10 mg/kg, po after 8 days relative to control
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