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Jurkat Latency Reversal Assay from US Patent US11492361: "Compounds useful in HIV therapy"
Assay data:59 Active, 59 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant p66/p51 HIV-1 RNase H using 6-FAM-labeld DNA substrate preincubated for 2 mins by fluorescence based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation at 500 nM using poly(A)/oligo (dT)15 as template/primer by ELISA relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation at 100 nM using poly(A)/oligo (dT)15 as template/primer by ELISA relative to control
Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant wild-type p66/p51 HIV-1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
Assay data:32 Active, 19 Activity ≤ 1 µM, 40 Tested
Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction of biotin-dUTP incorporation into protein using ABTS as substrate incubated for 1 hrs by ELISA analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of HIV-1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorometric analysis
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
Potency index, ratio of test compound IC50 to NBD-14189 IC50 for inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assay
Assay data:15 Tested
Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assay
Assay data:8 Active, 1 Activity ≤ 1 µM, 16 Tested
Inhibition of HIV-1 reverse transcriptase using rC.dG as primer/template
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [8,5'-3H]dGTP from HIV-1 reverse transcriptase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of HIV-1 reverse transcriptase at 10 ug/ml by fluorescence based plate reader assay relative to control
Assay data:2 Tested
Inhibition of wild type HIV-1 Reverse transcriptase
Assay data:40 Active, 9 Activity ≤ 1 µM, 49 Tested
Inhibition of wild-type recombinant HIV-1 group M subtype B BH10 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia coli XL1 blue at 100 uM using 32P-labeled 5'-UUUUUUUUUAGGAUACAUAUGGUUAAAGUAU-3'/5'-ATACTTTAACCATATGTATCC-3' RNA/DNA template-primer as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by phosphorimaging analysis relative to control
Assay data:7 Tested
Potency index, ratio of beta-thujaplicinol IC50 to test compound IC50 for inhibition of wild-type recombinant HIV-1 group M subtype B BH10 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia coli XL1 blue
Inhibition of wild-type recombinant HIV-1 group M subtype B BH10 reverse transcriptase RNase-associated RNase H activity expressed in Escherichia coli XL1 blue using 32P-labeled 5'-UUUUUUUUUAGGAUACAUAUGGUUAAAGUAU-3'/5'-ATACTTTAACCATATGTATCC-3' RNA/DNA template-primer as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by phosphorimaging analysis
Assay data:15 Active, 13 Activity ≤ 1 µM, 24 Tested
Inhibition of HIV-1 reverse transcriptase at 200 ug/ml using poly(A) ribonucleotide as template and oligo d(T)16 as primer incubated for 1 hr by PicoGreen DNA fluorescence assay relative to control
Inhibition of HIV-1 LTR reverse transcriptase infected in human CEM cells using RNA template incubated for 1 hr by RT-PCR based cell-free assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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