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In Vitro Assay Dipeptidyl Peptidase IV. Fibroblast Activation Protein and Prolyl Oligopeptidase from US Patent US11707539: "FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto"
Assay data:89 Active, 7 Activity ≤ 1 nM, 89 Activity ≤ 1 µM, 89 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Inhibition Assay from US Patent US11583516: "Dash inhibitors, and uses related thereto"
Assay data:13 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
EnPlex (purified enzyme activity assay) from US Patent US11559537: "Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists"
Assay data:49 Active, 10 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 50 Tested
DPPIV Enzymatic Activity Assay from US Patent US11504364: "Inhibitors of fibroblast activation protein"
Assay data:46 Active, 36 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human DPP4 using Gly-Pro-AMC as substrate incubated for 30 mins by continuous fluorescent assay
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to DPP4 (unknown origin) assessed as binding constant by isothermal titration calorimetry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to DPP4 (unknown origin) assessed as gibbs free energy change by isothermal titration calorimetry
Binding affinity to DPP4 (unknown origin) assessed as change in entropy by isothermal titration calorimetry
Binding affinity to DPP4 (unknown origin) assessed as change in enthalpy by isothermal titration calorimetry
Binding affinity to DPP4 (unknown origin) assessed as Km by Michaelis-Menten analysis
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate incubated for 30 mins by fluorescence based enzyme immunoassay
Assay data:18 Active, 10 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of DPP4 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Serine protease panel) EUB0000735a DPP4
SummaryRelated BioAssays by Target
Inhibition of human DPP4 expressed in Silkworm baculovirus system preincubated for 30 mins followed by substrate addition and measured after 20 mins using Gly-Pro-4-methylcoumarin-7-amide as substrate by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested
Stability of compound assessed as DPP4 (unknown origin)-mediated hydrolysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of DPP4 in human Caco-2 cells using Gly-Pro-AMC as substrate at 5 uM incubated for 60 mins by fluorescence based microplate reader assay
Inhibition of DPP4 in human Caco-2 cells using Gly-Pro-AMC as substrate at 100 nM incubated for 60 mins by fluorescence based microplate reader assay
Inhibition of DPP4 in human Caco-2 cells using Gly-Pro-AMC as substrate at 1 uM incubated for 60 mins by fluorescence based microplate reader assay
Inhibition of DPP4 in human Caco-2 cells using Gly-Pro-AMC as substrate at 20 nM incubated for 60 mins by fluorescence based microplate reader assay
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