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Affinity Biochemical interaction (Microtiter-based biochemical assay) EUB0000737a ELANE
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Biochemical interaction (Microtiter-based biochemical assay) EUB0000735a ELANE
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potency index, ratio of JO146 IC50 to test compound IC50 for inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pNA as substrate incubated for 10 mins
Assay data:18 Active, 18 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of native full length human neutrophil elastase using N-succinyl-Ala-Ala-Pro-Val-pNA as substrate at 5 uM incubated for 30 mins followed by substrate addition by fluorescence based analysis
Inhibition of human neutrophil elastase using methoxysuccinyl-Ala-Ala-Pro-Val-pnitroanilide as substrate by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human leukocyte elastase
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human Neutrophil elastase using MeO-SucAlaAla-Pro-Val-AMC as substrate measured for 30 mins by fluorescence microplate reader analysis
Assay data:1 Active, 1 Tested
Competitive inhibition of human neutrophil elastase using fluorogenic substrate by double-reciprocal Lineweaver-Burk plot analysis
Assay data:2 Active, 2 Tested
Inhibition of human neutrophil elastase at 50 uM
Assay data:15 Tested
Inhibition of human neutrophil elastase
Assay data:12 Active, 12 Activity ≤ 1 µM, 14 Tested
Inhibition of human neutrophil elastase incubated for 40 mins in presence of Boc-Gln-Ala-Arg-AMC by fluorescence microtiter plate method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of neutrophil elastase (unknown origin) at 0.96 to 96.15 uM
Assay data:10 Tested
Binding affinity to human neutrophil elastase assessed as inhibition constant using Methoxysuccinyl-L-alanyl-L-alanyl-L-prolylL-valine p-Nitroaniline as substrate measured upto 120 mins by spectrophotometric analysis
Inhibitory Activity Assay from US Patent US11168083: "Inhibitors of Plasma Kallikrein and uses thereof"
Assay data:42 Active, 27 Activity ≤ 1 µM, 66 Tested
Chromogenic Enzyme Activity Assays from US Patent US11149067: "Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors"
Assay data:31 Active, 19 Activity ≤ 1 µM, 33 Tested
Human Neutrophil Elastase Assay from US Patent US9458113: "Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity"
Assay data:184 Active, 19 Activity ≤ 1 nM, 184 Activity ≤ 1 µM, 184 Tested
Human Neutrophil Elastase Assay from US Patent US9475779: "Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity"
Assay data:55 Active, 26 Activity ≤ 1 nM, 53 Activity ≤ 1 µM, 55 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Elastase Activity Assay from Article 10.3109/14756366.2012.692086: "Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines."
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
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