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Enzymatic Activity Assay from US Patent US20230391761: "SUBSTITUTED S-ALANINATE DERIVATIVES"
Assay data:17 Active, 14 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Human Cytochrome P450 Inhibition Assay from US Patent US11834414: "1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use"
Assay data:5 Active, 15 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS for inhibitors of CYP2D6 against the NCATS DSHEA and TCM libraries
Assay data:85 Active, 1 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzymatic Activity Assay from US Patent US20230348459: "PYRROLIDINE COMPOUND AND USE THEREOF"
Assay data:1 Active, 3 Tested
Inhibition Against Cytochrome P450 Isoenzymes from US Patent US20230331739: "INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME"
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme (Cytocrome P450) Inhibition Assay from US Patent US20230303562: "PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:6 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
CYP P450 Enzyme Inhibition from US Patent US11752155: "Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders"
Assay data:7 Active, 1 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Cytochrome P450 Oxidase from US Patent US11643436: "Polypeptide compound, pharmaceutical composition, preparation method and application thereof"
Inhibition Assay from US Patent US11548860: "Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1"
Assay data:11 Active, 3 Activity ≤ 1 µM, 13 Tested
CYP Inhibition Assay from US Patent US11505526: "Aryl-piperidine derivatives"
Assay data:2 Active, 3 Tested
Inhibition of CYP2D6 (unknown origin) at 10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP450 (unknown origin)
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate in presence NADPH regenerating system
Inhibition of human hepatic CYP2D6 using bufuralol HCL as substrate measured after 3 mins by LC-MS analysis relative to control
Assay data:8 Tested
Inhibition of CYP2D6 in human liver microsomes at 10 uM using bufuralol as substrate preincubated for 5 mins followed by addition of NADPH measured after 10 mins by LC/MS/MS analysis relative to control
Inhibition of CYP2D6 in human liver microsomes at 0.01 to 30 uM using dextromethorphan as substrate in presence of NADPH by UPLC-MS/MS analysis
Inhibition of CYP2D6 in human liver microsomes at 25 uM in the presence of NADPH
Inhibition of CYP2D6 (unknown origin) at 20 uM
Assay data:5 Tested
Inhibition of CYP2D6 in human liver microsomes
Assay data:2 Tested
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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